PPAN – Wikipedia

PPAN - Wikipedia

Suppressor of SWI4 1 homolog is a protein that in people is encoded by the PPAN gene.[5][6]

The protein encoded by this gene is an evolutionarily conserved protein much like yeast SSF1 in addition to to the gene product of the Drosophila gene peter pan (PPAN). SSF1 is understood to be concerned within the second step of mRNA splicing. Each SSF1 and PPAN are important for cell progress and proliferation. This gene was discovered to cotranscript with P2RY11/P2Y(11), a right away downstream gene on the chromosome that encodes an ATP receptor. The chimeric transcripts of this gene and P2RY11 have been discovered to be ubiquitously current and controlled throughout granulocytic differentiation. Exogenous expression of this gene was reported to scale back the anchorage-independent progress of some tumor cells.[6]

Though being concerned in ribosome biogenesis, human PPAN is just not merely localized in nucleoli, but in addition in mitochondria. Depletion of PPAN provokes apoptosis as noticed by elevated quantities of p53 and its goal gene p21, BAX-driven depolarisation of mitochondria, cytochrome c launch in addition to caspase-dependent cleavage of PARP.[7] Current research revealed that PPAN participates within the regulation of mitochondrial homeostasis, presumably through modulation of autophagy.[8] Moreover, PPAN is required for correct biking of cells since down regulation of PPAN in most cancers cells leads to a p53-independent cell cycle arrest.[9]

One of many introns of PPAN encodes the Small nucleolar RNA SNORD105.[10]


  1. ^ a b c GRCh38: Ensembl launch 89: ENSG00000130810 – Ensembl, Might 2017
  2. ^ a b c GRCm38: Ensembl launch 89: ENSMUSG00000004100 – Ensembl, Might 2017
  3. ^ “Human PubMed Reference:”. Nationwide Heart for Biotechnology Info, U.S. Nationwide Library of Drugs.
  4. ^ “Mouse PubMed Reference:”. Nationwide Heart for Biotechnology Info, U.S. Nationwide Library of Drugs.
  5. ^ Welch PJ, Marcusson EG, Li QX, Beger C, Krüger M, Zhou C, et al. (June 2000). “Identification and validation of a gene concerned in anchorage-independent cell progress management utilizing a library of randomized hairpin ribozymes”. Genomics. 66 (3): 274–83. doi:10.1006/geno.2000.6230. PMID 10873382.
  6. ^ a b “Entrez Gene: PPAN peter pan homolog (Drosophila)”.
  7. ^ Pfister AS, Keil M, Kühl M (April 2015). “The Wnt Goal Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway”. The Journal of Organic Chemistry. 290 (17): 10905–18. doi:10.1074/jbc.M114.634246. PMC 4409253. PMID 25759387.
  8. ^
  9. ^ Keil M, Meyer MT, Dannheisig DP, Maerz LD, Philipp M, Pfister AS (Might 2019). “Lack of Peter Pan protein is related to cell cycle defects and apoptotic occasions”. Biochimica et Biophysica Acta (BBA) – Molecular Cell Analysis. 1866 (5): 882–895. doi:10.1016/j.bbamcr.2019.01.010. PMID 30716409.
  10. ^ Vitali P, Royo H, Seitz H, Bachellerie JP, Hüttenhofer A, Cavaillé J (November 2003). “Identification of 13 novel human modification information RNAs”. Nucleic Acids Analysis. 31 (22): 6543–51. doi:10.1093/nar/gkg849. PMC 275545. PMID 14602913.

Additional studying[edit]

  • Communi D, Govaerts C, Parmentier M, Boeynaems JM (December 1997). “Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase”. The Journal of Organic Chemistry. 272 (51): 31969–73. doi:10.1074/jbc.272.51.31969. PMID 9405388.
  • Migeon JC, Garfinkel MS, Edgar BA (June 1999). “Cloning and characterization of peter pan, a novel Drosophila gene required for larval progress”. Molecular Biology of the Cell. 10 (6): 1733–44. doi:10.1091/mbc.10.6.1733. PMC 25365. PMID 10359593.
  • Suarez-Huerta N, Boeynaems JM, Communi D (August 2000). “Cloning, genomic group, and tissue distribution of human Ssf-1”. Biochemical and Biophysical Analysis Communications. 275 (1): 37–42. doi:10.1006/bbrc.2000.3259. PMID 10944437.
  • Communi D, Suarez-Huerta N, Dussossoy D, Savi P, Boeynaems JM (Might 2001). “Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes”. The Journal of Organic Chemistry. 276 (19): 16561–6. doi:10.1074/jbc.M009609200. PMID 11278528.
  • Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, et al. (January 2002). “Directed proteomic evaluation of the human nucleolus”. Present Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Duhant X, Schandené L, Bruyns C, Gonzalez NS, Goldman M, Boeynaems JM, Communi D (July 2002). “Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes”. Journal of Immunology. 169 (1): 15–21. doi:10.4049/jimmunol.169.1.15. PMID 12077223.
  • Scherl A, Couté Y, Déon C, Callé A, Kindbeiter Ok, Sanchez JC, et al. (November 2002). “Purposeful proteomic evaluation of human nucleolus”. Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). “Massive-scale characterization of HeLa cell nuclear phosphoproteins”. Proceedings of the Nationwide Academy of Sciences of the USA of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). “Phosphoproteome evaluation of the human mitotic spindle”. Proceedings of the Nationwide Academy of Sciences of the USA of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). “A probability-based method for high-throughput protein phosphorylation evaluation and web site localization”. Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). “International, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). “Massive-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Methods Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Related posts

Leave a Comment